That being said, broad-spectrum, class-specific or isoform-specific HDAC inhibitors have been reported to have anti-fibrotic effects in non-diabetic rodent models of renal fibrosis, including the unilateral ureteral obstruction model [95,96,97,98,99,100,101,102] and the rat remnant kidney model [88]. Here, HDAC9 is linked to renal fibrosis.