Wang and co-workers, reported increased expression of HDAC2, HDAC4, and HDAC5 in the kidneys of STZ-diabetic rats and db/db mice and increased expression of HDAC4 and HDAC5 in the kidneys of humans with diabetic kidney disease, with an inverse correlation between estimated glomerular filtration rate (eGFR) and the expression of either HDAC2, HDAC4, or HDAC5 [55]. This evidence concerns the gene HDAC2 and diabetic kidney disease.