Cytosolic Hsp60 has a pro-apoptotic role: it binds pro-caspase 3 allowing its activation in normal cells [121] but, in tumor cells, Hsp60 does not activate the caspase pathway assuring malignant cell survival and, thus, contributes to tumorigenesis [122] by playing an antiapoptotic role [123]. This evidence concerns the gene CASP3 and neoplasm.