Regarding the regulatory potential of miRNAs in Hsp expression, it has been demonstrated that miR-628-3p affected migration and apoptosis in lung cancer cells, downregulating Hsp90a protein expression via a post-transcriptional mechanism [133], and that the oncogene Hsp90B1 is a direct target of the tumor suppressor miR-223 in a cell model of human osteosarcoma [134]. This evidence concerns the gene HSP90AA1 and osteosarcoma.