BCL2 and cancer: Polyphenol ability to induce apoptotic cell death is associated with a decreased expression of the anti-apoptotic protein Bcl-2, which is paralleled with the increase of pro-apoptotic proteins such as BAX, Bak, and Bim, as well with the upregulation of p53, p21, and p27 in several type of cancer cells (for a review, see [46].