Accordingly, genistein inhibits the tumor growth and distant metastasis of mice colorectal tumor [133], where the ERβ-mediated functions prevail (for a review, see [176]), and, through an ER-mediated mechanism, genistein favors cell adhesion, impairing the migration of DU145 and PC3 prostate cancer cells, which express only ERβ subtypes [132]. This evidence concerns the gene ESR2 and Familial prostate cancer.