Cribriform carcinoma comprises only epithelial cells and no basement membrane-like materials in the spaces and usually expresses ER and PR, whereas ACC of the breast usually does not express ER, PR, and HER2 and tends to express CK5/6 or EGFR and EGFR is potentially an important therapeutic target [10]. The gene discussed is ERBB2; the disease is adrenal cortex carcinoma.