BRCA1 and breast cancer: Similar to ACCs of the salivary gland, ACCs of the breast are characterized by the t(6;9) (q22-23; p23-24) chromosomal translocation, which generates fusion transcripts involving the oncogene MYB and the transcription factor gene NFIB. Approximately 7% of breast cancer cases are related to hereditary conditions and caused by mutations in the BRCA1 and BRCA2 genes.