Importantly, the same concentration of the chemically similar but biologically inert molecule succinimide conferred no protection from PTZ-induced convulsions in single unc-49 mutants (Fig. 6) or double unc-49;cca-1 mutants (Supplementary video S7), demonstrating that the anticonvulsant activity of ethosuximide was specific to the drug and not due to non-specific effects of the treatment conditions. Here, TRNT1 is linked to convulsion.