ADAM 17 came to prominence due to its ability to shed the soluble form of the inflammatory cytokine, TNFα from it precursor product [75, 76], however, despite TNFα being widely implicated in tumour development and progression, it is the ability of ADAM 17 to hydrolyse and promote the release of epidermal growth factor receptor (EGFR)/human EGFR (HER) precursor ligands that features most frequently in published studies. This evidence concerns the gene TNF and neoplasm.