ANGPT1 and arthritic joint disease: In addition, patients with a global arthritis score >7 were more likely to have increased sVCAM-1 (832±272 ng/mL vs. 704±227 ng/mL P = 0.013), Tie 2 (17.9±8.3 ng/mL vs.13.7±5.2 ng/mL, P = 0.002), Angiopoietin-1 levels (61049±40829 pg/mL vs. 47530±27002 pg/mL, P = 0.043) and Angiostatin (29.3±45.8 ng/mL vs. 15.5±20.5 ng/mL, P = 0.025) than patients with a score ≤7 (Fig 3A–3H).