CTSB and hydrops fetalis: In a recent study, variation of the immune-proteome profile of HF along the cyst progression has been shown [25], with patients having CE2 and CE3 stages exhibiting strong antibody responses against diverse AgB and Ag5 proteoforms, while sera from patients with CE1, CE4, and CE5 stages mainly reacting to Ag5 and cathepsin B but not against AgB proteins.