Accordingly, we clarify the associations of SNPs in the SEPP1, SELENOS, TXNRD1, TXNRD2, GPX4, and SOD2 genes, and the selenoprotein P (SeP) and thioredoxin (Trx) concentrations with the development of AAA and AIOD/PAD, as well as their influence on cardiac phenotype (history of coronary artery disease (CAD), myocardial infarction (MI), and systolic HF) in these diseases. Here, GPX4 is linked to peripheral arterial disease.