Accordingly, we clarify the associations of SNPs in the SEPP1, SELENOS, TXNRD1, TXNRD2, GPX4, and SOD2 genes, and the selenoprotein P (SeP) and thioredoxin (Trx) concentrations with the development of AAA and AIOD/PAD, as well as their influence on cardiac phenotype (history of coronary artery disease (CAD), myocardial infarction (MI), and systolic HF) in these diseases. This evidence concerns the gene TXN and peripheral arterial disease.