These alleles were related to a 40–61% higher probability of occurrence of PAD/AIOD in the analyzes, which compared the frequency of genotypes between the subgroup of AAA patients with PAD and the control group (GPX4: OR = 1.41), the subgroup of AAA patients with PAD and the subgroup of AAA patients without PAD (SEPP1: OR = 1.52, GPX4: OR = 1.58), the AIOD patients and the control group (SELENOS: OR = 1.61), and the AIOD patients and the subgroup of AAA patients without PAD (GPX4: OR = 1.4; Fig 1A and S3 Table). The gene discussed is SELENOP; the disease is peripheral arterial disease.