GPX4 and obesity due to melanocortin 4 receptor deficiency: The SEPP1 rs3877899 and rs7579 SNPs have been associated with metabolic phenotypes related to diabetes [28], while different GPX4 variants were linked with the concentration of inflammatory biomarkers [27], glutathione peroxidase activity [45], lipid metabolism [46], as well as obesity [45], cerebral stroke [25], and endothelial dysfunction [26].