Interestingly, analysis of phenotype of carriers of the GPX4/SELENOS double homozygous genotype in AIOD in relation to phenotype of carriers of other genotype combinations, showed not only a positive correlation with the patient’s age (65.47 ± 5.74 versus 60.56 ± 8.67, P = .031), but also associations with a higher incidence of diabetes (7.7% versus 2.7%, P = .029) and obesity (9.8% versus 3.1%, P = .025). This evidence concerns the gene GPX4 and obesity due to melanocortin 4 receptor deficiency.