ETV4 and cancer: Reevaluating the available ChIP-seq data from the human LoVo and GIST48 cancer cell lines [21, 22], we found that all of the above negative and positive feedback genes could be bound by either PEA3, ERM or ER81 in their promoter (within 5000 bp of the transcriptional start site) and/or enhancer regions (beyond 5000 bp upstream or downstream to the promoter site) (Fig 3A and 3B).