PTPRJ and melanoma: Although regional LOH on chromosome 18 was observed by SNP array in three of six cases bearing single mutations in PTPRJ, these regions were not observed to directly overlap the coding region of PTPRJ. Overall, the enrichment for PTPRJ truncating mutation in canine malignant melanoma bears intriguing implications both for a previously underappreciated role for this gene in human melanoma (e.g. through as-yet understudied roles for hemizygous deletion [124] and/or epigenetic modifications) and for the possibility of unique mechanisms of tumorigenesis across species.