Our WGS discovery cohort primarily consisted of Cocker Spaniels (four Cocker Spaniels, one English Cocker Spaniel, and one Labrador), a breed reported to be at higher risk of oral melanoma, but our extended cohort then included targeted sequencing of 13 melanoma hallmark genes (as well as PTPRJ, which was the only additional recurrently mutated gene in the WGS cohort) and copy number assessment from SNP arrays across 20 total breeds. The gene discussed is PTPRJ; the disease is melanoma.