KIT mutations in the mucosal cases included an in-frame deletion of amino acids 560–562, a likely damaging mutation in a commonly mutated region of the human ortholog, as well as an aspartic acid (D) to valine (V) change in codon 815 corresponding to the most common hotspot D816V mutations occurring in the kinase domain of KIT in human cancers (S5 Fig) [59]. This evidence concerns the gene KIT and cancer.