Nine of 10 GISTIC regions contained genes and included gains in orthologs of the human cancer genes MDM2 and CDK4. Additional cancer driver alterations (homozygous deletions of tumor suppressor genes or focal amplifications of oncogenes) included CDKN2A homozygous deletion (3%) and KIT focal amplification (8%) (S7 Table). This evidence concerns the gene CDK4 and cancer.