For instance, the lncRNA AK055347 contributed to the pathogenesis of AF via the regulation of Cyp450, ATP synthase and MSS51.53 Up‐regulated miR‐208b abolished the expression and function of CACNA1C, CACNB2 and SERCA2 during atrial remodelling.54 lncRNA could mediate electrical remodelling during AF through interacting with miRNA and its target mRNA. This evidence concerns the gene ATP2A2 and atrial fibrillation.