This contradicts the idea of type 2 diabetes, in which the level of insulin would increase, along with the number and volume of Langerhans islets.15 Instead, type 1 diabetes mellitus (T1DM) characterized by insulin deficiency caused by pancreatic β-cell loss leading to hyperglycemia might be a better explanation, but nonetheless we need further investigations of the presence of related autoantibodies, proteomics, insulin dependence, and insulitis. This evidence concerns the gene INS and type 2 diabetes mellitus.