ANXA5 and neoplasm: In the pre-clinical studies, blockade of PtdSer using either Annexin V protein or anti-PtdSer mAb promoted anti-tumor immunity through induction of M1-macrophage polarization, increased dendritic cell maturation and antigen presentation, and increased presence of CD8+ cytotoxic T cells within the tumor microenvironment [86, 88, 89, 92].