The comparison of the TNF inhibitors (IFX, ETA, ADA, GLM, and CZP) with the non-TNF inhibitors (TCZ and ADA) revealed that the frequency of hospitalized infection was 23 of 316 patients (7.3%) and 12 of 129 patients (9.3%), respectively, with no significant difference (p = 0.5604). The gene discussed is TNF; the disease is infection.