Methyl-β-cyclodextrin (MβCD), a water-soluble polymer and a cyclic oligosaccharide, absorbs cholesterol from the cell membrane and has been shown to impair actin polymerization, cell migration, Akt (also known as protein kinase B, PKB) phosphorylation, protein kinase C translocation, and EGF-induced cell adhesion in selective cancer cell models [23, 87, 88]. The gene discussed is AKT1; the disease is cancer.