Considering that the APO-type peptides increase macrophage production in infected tissues (Ostorhazi et al., 2013) and macrophages produce high levels of IL-10 during infection (Couper et al., 2008), the combined inflammatory cytokine profile can be considered both a result and a driving force of Chex1-Arg20 amide efficacy in protecting mammals from infection and regulating host immune responses. This evidence concerns the gene IL10 and infection.