The median serum hepcidin-25 level in the CHC group was 7.2 ng/mL (range, 0-27.3) and was 23.3 ng/mL (range, 3.9-47.3) in the control group, with the CHC group having a significantly lower value (Figure 2; P = 0.0002). Here, HAMP is linked to cryohydrocytosis.