CTSD and infection: Interestingly, during early infection, inhibition of c-Fos signaling caused the reduction in the expression levels of a few important trafficking regulators and hydrolytic enzymes, including Lamp1, Rab5a, CtsD and Gla (Figures 5A,C); however, interference of c-Fos signaling was discovered to have greater influence on phagolysosome-related gene expression at 24 h post-infection, with reduction in the levels of 11 transcripts, namely, Lamp2, Rab14, Rab22a, Rab32, Gla, HexB, CtsA, CtsC, CtsL, CtsO, and CtsS, compared with control cells (Figures 5B,D).