Interestingly, during early infection, inhibition of c-Fos signaling caused the reduction in the expression levels of a few important trafficking regulators and hydrolytic enzymes, including Lamp1, Rab5a, CtsD and Gla (Figures 5A,C); however, interference of c-Fos signaling was discovered to have greater influence on phagolysosome-related gene expression at 24 h post-infection, with reduction in the levels of 11 transcripts, namely, Lamp2, Rab14, Rab22a, Rab32, Gla, HexB, CtsA, CtsC, CtsL, CtsO, and CtsS, compared with control cells (Figures 5B,D). The gene discussed is CTSO; the disease is infection.