Additionally, the loss of IFN-γ pathway genes IFNGR1, IFNGR2, JAK2, IRF1, IFIT1, IFIT3, MTAP, miR31 and amplification of the suppressor genes SOCS1 and PIS4 have been shown in melanoma patients non-responsive to anti-CTLA4 therapy. This evidence concerns the gene IFIT1 and melanoma.