PPARα is activated by both endogenous and synthetic ligands; the former includes long‐chain polyunsaturated fatty acids and eicosanoids such as leukotriene B4 and the latter includes fibrates such as fenofibrate, bezafibrate, and clinofibrate, the drugs for the treatment of hypertriglyceridemia 24. The gene discussed is PPARA; the disease is hypertriglyceridemia.