Nine hub target genes, namely PRKACB, ITGA4, PAFAH1B1, PIK3R1, ESR1, EFNB2, ATP2B1, AKT3, and LAMC1, may have a close association with the tumorigenesis, disease progression, invasion, and metastasis of GC. The gene discussed is EFNB2; the disease is gastric cancer.