In addition, we could recently show [47] that local upregulation of proinflammatory and proosteogenic molecules such as CRP, CD40, CD154, and SATB2 as well as galectin-3 is already present at early stages of CKD in various vessels (Figure 2), i.e., the A. mammaria int., the V. saphena magna, and the aorta taken at the occasion of cardiac surgery [47]. The gene discussed is CD40LG; the disease is chronic kidney disease.