Various compounds including CIN were shown to promote NRF2-mediated HMOX1 and NQO1 genes in several cells such as fibroblasts, keratinocytes, endothelial cells, epithelial colon cells, and cardiomyocytes [29, 51, 53–55]. Here, NFE2L2 is linked to cervical squamous intraepithelial neoplasia.