NFE2L2 and cervical squamous intraepithelial neoplasia: As expected, under our experimental conditions, CIN induced the cytoplasmic-to-nuclear translocation of NRF2 and the NRF2 activation upregulated the expression of HMOX1 and NQO1 at the mRNA level, but only the expression of HMOX1 at the protein level (Figure 1).