According to the univariate logistic regression, the elevation of each biomarker presented in Table 2 (omentin, leptin, VEGF, HGF, and PSA) suggests a statistically significant higher risk of prostate cancer development (OR: 1.005, p = 0.01; OR: 1.053, p = 0.02; OR: 1.010, p < 0.01; OR: 1.003, p = 0.03; OR: 1.090, p = 0.01, resp). This evidence concerns the gene KLK3 and Familial prostate cancer.