Akt signaling pathway is known for its role in cardiac hypertrophy (Condorelli et al., 2002; Predmore et al., 2010; Chen et al., 2013; Maillet et al., 2013; Jiang et al., 2015), however, the exact mechanism by which TRAF2 specifically activating Akt pathway is not clear. This evidence concerns the gene TRAF2 and cardiac hypertrophy.