In response to pressure overload by aortic banding (AB), TRAF3-knockout mice demonstrated significantly decreased cardiac hypertrophy after 4 weeks as depicted by individual cardiomyocyte cross-sectional area along with reduced cardiac fibrosis and preserved cardiac function as seen in reduction in HW/BW, HW/TL and lung weight/BW (LW/BW) ratios. This evidence concerns the gene TRAF3 and cardiac hypertrophy.