Increasing amount of literature suggests the vital role played by NF-κB signaling pathway in regulating the process of cardiac hypertrophy and heart failure (Purcell et al., 2001; Li et al., 2004; Freund et al., 2005; Zelarayan et al., 2009; Santos et al., 2010; Gordon et al., 2011; Leychenko et al., 2011). The gene discussed is NFKB1; the disease is heart failure.