In an effort to elucidate other mechanistic pathways that might be involved in FXTAS, Ladd et al. (2007) identified a novel gene, the antisense FMR1 (ASFMR1), the main identified non-coding RNA (ncRNA) at the FMR1 locus. Here, FMR1-AS1 is linked to fragile X-associated tremor/ataxia syndrome.