RAN and fragile X-associated tremor/ataxia syndrome: Moreover, it was previously found that RAN translation, which is one of the mechanisms proposed to explain the pathogenesis of FXTAS, also occurs in the antisense direction generating novel proteins that accumulate in ubiquitinated inclusions in FXTAS patients (Krans et al., 2016) further supporting the potential role of the antisense transcript in FXTAS.