Importantly, this study aimed to identify molecular biomarkers at the FMR1 locus (FMR1, ASFMR1, and ASFMR1 131 bp splicing isoform) that may correlate with early emergence of movement abnormalities in premutation carriers without FXTAS and might be helpful as potential biomarkers in longitudinal studies. This evidence concerns the gene FMR1 and fragile X-associated tremor/ataxia syndrome.