Other mutations also known to affect multiplication and movement of viruses for viral infection include those in genes encoding seven-pass membrane proteins [Tobamovirus multiplication 1 (TOM1) and (TOM2); Yamanaka et al., 2002; Ishibashi and Ishikawa, 2016], a small GTP-binding ARF-family protein (ARL8; Nishikiori et al., 2011), a chloroplast phosphoglycerate kinase (cPGK2; Ouibrahim et al., 2014), cell-to-cell transporter [potyvirus VPg-interacting protein 1 and 2 (PVIP1) and (PVIP2); Dunoyer et al., 2004], and calcium sensors (Lewis and Lazarowitz, 2010). Here, TOM1 is linked to viral infectious disease.