Meanwhile, short-term reduction of miR-223 expression with miR-223 inhibitors enhanced susceptibility to LPS-induced endometritis, and intervention with miR-223 mimics led to a reduction in NLRP3 production that translated into a decreased capacity to generate biologically active IL-1β, thus increasing the susceptibility to those genital tract microorganisms, which are especially susceptible to destruction following the induction of these pro-inflammatory cytokines/chemokines. The gene discussed is NLRP3; the disease is endometritis.