The NLRP3 inflammasome can sense many different factors, such as LPS, and upon activation, the assembly of the inflammasome results in the cleavage and activation of caspase-1, with constitutive IL-1β production resulting in serious inflammatory disorders (36), including type 2 diabetes (T2D), gout, atherosclerosis, and neurodegenerative diseases (37–39).Therefore, activation of the inflammasome needs to be strictly controlled to prevent excessive inflammation. Here, CASP1 is linked to atherosclerosis.