In this review, we aim to discuss our current understanding of the combinatorial interactions between PPARγ and its interaction partners and how their dynamic changes impact PPARγ downstream target gene transactivation under different metabolic scenario and during the aging process in adipose tissues, thus potentially provide us with more elaborate and precise strategies to screen novel therapeutic targets that target PPARγ and its cofactors in treating adipocyte dysfunctions and metabolic diseases. Here, PPARG is linked to Other metabolic disease.