A large number of studies on the role of NF-κB in the pathogenesis of cancer followed the observations that NF-κB transcription factors have homology with the avian oncogene v-REL, which causes reticuloendotheliosis and lymphoma in poultry (53), and that human c-REL can induce transformation of primary chicken spleen cells (54). Here, NFKB1 is linked to cancer.