Reducing the release of succinate from mitochondria, blocking of GPR91 in the membrane levels or SDH regulation by SIRT3 or de-succinylation might be a candidate targets but further study was needed to evaluate the exact down-steam pathway of succinate-GPR91 and discover the powerful exact drug target which may induce alleviation or regression of liver fibrosis. Here, SIRT3 is linked to Hepatic fibrosis.