One study showed that increasing SIRT3 expression in HSCs with adenoviral transfection or supplementation of resveratrol in methionine choline deficient (MCD) diet-fed mice led to a decrease in HSCs activation and alleviated hepatic fibrosis through the SDH-succinate-GPR91 pathway in vivo (42). Here, SUCNR1 is linked to Hepatic fibrosis.