EGFR and non-small cell lung carcinoma: There is also data showing that metformin has synergistic effects with various chemotherapy agents, including Pemetrexed in cell lines of non-small cell lung cancer (NSCLC), (85) EGFR-TKI in patients with NSCLC (86), Trichostatin in osteosarcoma cell lines (87), Simvastatin in animal models of metastatic prostate cancer (88) and Nelfinavir in cervical cancer xenografts (89).