MMP2 and androgen insensitivity syndrome: Herein, MMP-2 (green) and MMP-9 (red) (Figures 4A,B) exhibited critical roles in the disruption of the BBB that occurred during AIS as both were upregulated in peri-infarct regions, as assessed by IF detection (Figures 4C,D); however, the increases in MMP-2 and MMP-9 were reduced following both normal- and high-dose rosuvastatin therapy (Figure 4B, P < 0.05 vs. SHAM).