TP53 and cancer: Particularly, numerous studies have demonstrated that curcumin targets many therapeutically important cancer signaling pathways such as STAT3 (Blasius et al., 2006; Chakravarti et al., 2006), HER2 (Aggarwal et al., 2003), Notch (Subramaniam et al., 2012), p53, Ras, Wnt-β catenin (Leow et al., 2010), NF-κB (Epstein et al., 2010), phosphatidylinositol-4,5-bisphosphate 3-kinase, AKT (Chiablaem et al., 2014), and mechanistic target of rapamycin (Seo et al., 2014) signaling pathways, among others.