NFKB1 and cancer: It has been indicated that curcumin targets different biochemical pathways, such as those mediated by HER2 (Aggarwal et al., 2003), Wnt/β-catenin (Leow et al., 2010), Janus kinase (JAK)/STAT (Kim et al., 2003), and nuclear factor (NF)-κB (Epstein et al., 2010), to enhance its effect on cancer cells.