Furthermore, no significant effect of ApoE status was found on novelty P3a amplitude or latency in HC and aMCI, which corroborated previous finding that no significant differences in P3a indices between ApoE ε4+ and ApoE ε4- in mildly cognitively impairment patients (Reinvang et al., 2005). The gene discussed is APOE; the disease is Cognitive impairment.