Although disruption in resting-state networks has already been related to abnormal levels of cerebrospinal fluid (CSF) proteins (Aβ and 181Thr-phosphorylated tau, p-tau) in older adults (Jiang et al., 2016), amnestic mild cognitive impairment (aMCI) subjects (Canuet et al., 2015) and mild AD patients (Li et al., 2013; Celebi et al., 2016), no study has investigated whether CR is able to mitigate the effects of the pathology in network efficiency through graph theory analysis. Here, MAPT is linked to Alzheimer disease.