APOD and neurodegenerative disease: Our group and others have previously reported that in some human neurodegenerative diseases, reactive glial progression seems to be accompanied by an increase in Apo D expression being this increment much higher in astrogliosis areas, probably due to neuron injury or loss (Ordoñez et al., 2006; Bajo-Grañeras et al., 2011; Dassati et al., 2014).