In a 3-year prospective study of older people with and without dementia at baseline, non-demented women at age 85 (n = 3) who developed dementia during the follow-up had a higher CSF/serum albumin ratio than those not developing dementia (10.4 ± 2.0 vs. 6.0 ± 1.9; p = 0.007), suggesting that BCSFB disruption may occur before the onset of clinical symptoms (Skoog et al., 1998). This evidence concerns the gene ALB and dementia.