Though it has been reported that the activation of SIRT1 induced by resveratrol could augment the production of lipoxin A4 in some diseases, such as autism, obesity, diabetes mellitus, metabolic syndrome, depression, schizophrenia, and cancer (Diaz-Gerevini et al., 2016), the interrelationship of LAX4 and SIRT1 in sepsis induced by brain dysfunction need to be illustrated. Here, SIRT1 is linked to major depressive disorder.