GFAP and VimentinGFAP−/−Vim−/− miceBrain and spinal cord injuries (Pekny et al., 1999)Sciatic nerve lesion (Berg et al., 2013)Entorhinal cortex lesion (Wilhelmsson et al., 2004)Photothrombosis model for stroke (Liu et al., 2014)GFAP−/−Vimentin−/−PPT1 −/− mice5.Batten disease (Macauley et al., 2011)GFAP−/−Vimentin−/−in APPswe/PS1dE9 AD background6.Alzheimers disease (Kamphuis et al., 2014). The gene discussed is GFAP; the disease is early-onset autosomal dominant Alzheimer disease.