Furthermore, it has been noted by Cardona et al. (2006) that the CCR3, CCR5, CX3CR1, CXCR2 and CXCR3 expressed in microglia were associated with senile plaques, whereas expression of CX3CR1 was determined as high in microglia and its ligand CX3CL1 in neurons. Here, CX3CR1 is linked to Senile plaques.