MAPT and Alzheimer disease: The progressive irreversible neurodegeneration disorder, Alzheimer’s disease (AD), is characterized by visible abnormal microscopic structures, such as deposition of the extracellular insoluble amyloid-β peptide (Aβ) in neuritic plaques and hyperphosphorylated tau protein in the neurofibrillary tangles (NFT) of the brain (Amihăesei et al., 2013; Luna et al., 2013; Puzzo et al., 2015).