Thus, AVP is involved in thermoregulation, cooling operating via activation of a non-selective cationic channel in AVP hypothalamic releasing neurons (Sharif-Naeini et al., 2008) and in response to hyperosmotic stress with high-salt diets induce or exacerbate hypertension (Kim et al., 2011; Choe et al., 2015; Prager-Khoutorsky et al., 2017). Here, AVP is linked to hypertensive disorder.