Interestingly, high salt intake causes an increase of chloride levels ([Cl−]i) levels in AVP releasing neurons (involving a decrease of KCC2 and an activation of NKCC1), excitatory actions of GABA and AVP dependent hypertension (Kim et al., 2011; Prager-Khoutorsky et al., 2017). This evidence concerns the gene AVP and hypertensive disorder.