MTOR and brain disorder: In keeping with this, mTOR (mammalian Target of Rapamycin) which is a main upstream regulator of both ATG and UP (Zhao et al., 2015; Lenzi et al., 2016), has been widely implicated in synaptic plasticity and DA-related brain disorders (Lipton and Sahin, 2014; Ryskalin et al., 2018b).