ERK1 is regulated by the BDNF/TrkB signaling pathway (Mocchetti and Bachis, 2004; Numakawa et al., 2010), and the TrkB signaling pathway is activated during seizure induction has been demonstrated in varies epilepsy animal models including PTZ model (Wang et al., 2009; Liu et al., 2013; Hao et al., 2016; Enomoto et al., 2017). This evidence concerns the gene BDNF and epilepsy.