However, since m-calpain phosphorylation and cellular KCC2 regulation are likely more complicated regulated with multiple mechanisms, our data from 0 Mg2+ model also suggested that, at least with some parts, this process is dependent on [Ca2+]i level during seizure induction in 0 Mg2+ or many other epilepsy models. The gene discussed is SLC12A5; the disease is epilepsy.