One study reported that thioflavin-S-positive skein-like inclusions are present in only 28% of ALS cases (Robinson et al., 2013), while another study found that thioflavin-S-positive TDP-43 inclusions were present in most FTLD-TDP and ALS cases (Bigio et al., 2013). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.