Moreover, Che et al. also confirmed the contribution of B7-H6 in cellular function regulation of human glioma cells, and moreover, they also showed that, the knockdown of B7-H6 could also induce the increased expression levels of E-cadherin and Bcl-2 associated X protein, and the decreased expression levels of vimentin, N-cadherin, MMP-2, MMP-9 and survivin, which further supported that B7-H6 was involved in the promotion of cancer progression [23]. Here, MMP2 is linked to central nervous system cancer.