Just as we know, proliferation-related gene such as Ki67, PCNA, Cyclin B1, CyclinD1, PARP, Bcl2 and Bax, invasion and metastasis related genes such as MMP2, MMP9 and MMP14 play the key role in tumorgenesis and progression. It has been demonstrated that ZFAS1 could regulate the expression of above gene, thus promote the tumorgenesis and progression of various cancers such as melanoma, glioma, colorectal cancer and gastric cancer [26, 30, 37, 47]. Here, MMP14 is linked to cancer.