Considering the immunological impairment in DS individuals, we aimed to determine the prevalence of the polymorphisms -597G>A (rs1800797), -572G>C (rs1800796), and -174G>C (rs1800795) in the IL-6 gene and -1082A>G (rs1800896), -829C>T (rs1800871), and -592C>A (rs1800872) in the IL-10 gene and the serum level of IL-6 and IL-10 in these individuals in comparison with individuals without DS. The gene discussed is IL10; the disease is Dravet syndrome.