IL-6 -174G>C, -572G>C, and -597G>A polymorphisms have been investigated on the levels of this cytokine in inflammatory diseases such as systemic-onset juvenile chronic arthritis [17], age-related macular degeneration [61], type 2 diabetes [62], age-related macular degeneration [63], systemic lupus erythematosus [20], cognitive impairment [63], and dementia [64]. This evidence concerns the gene IL6 and Cognitive impairment.