ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: After removal of tetracycline from the drinking water, BCR-ABL expression is induced (tet-off system) in the HSC population and mice develop a CML-like disease, characterized by splenomegaly, myeloid hyperplasia and a reduction in erythrocytes and B-cells (Figure S1A-B).