The reduction in engrafted CD45+CD34+ CML cells following single PIK-III treatment, including primitive CD45+CD34+CD38−and CD45+CD34+CD133+ populations, confirmed the essential role of autophagy in the maintenance of the LSC pool (Figs. 5f-g; S6E). Here, PROM1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.