BCR and chronic myelogenous leukemia, BCR-ABL1 positive: To demonstrate that the phenotypic effects of Lys05 treatment on leukemic mice were primarily due to autophagy inhibition, we generated an autophagy deficient CML model by crossing the previously described Atg7flox/flox:Mx-Cre conditional knockout mice [23] with the Scl-tTa-BCR-ABL model.