NCOA4 and chronic myelogenous leukemia, BCR-ABL1 positive: Analysis of additional autophagy substrates by western blot, SQSTM1/p62, neighbour of BRCA1 gene 1 (NBR1) [27] and nuclear receptor coactivator 4 (NCOA4) [20, 28], revealed a consistent increase after Lys05 treatment (Fig. 2c), confirming that Lys05 inhibits autophagy in primary CML progenitor cells more consistently than clinically achievable concentrations of HCQ.